Pharmacology Assignment Example | Topics and Well Written Essays - 1250 words - 1

Pharmacology - Assignment Example Activated tyrosine kinase in turn activates the signalling pathways such as protein kinase C pathway, Scaffolding proteins, Ras/Raf mitogen – activated protein kinase pathway, and phosphoinositol 3’ – kinase/Akt pathway (Arora and Scholar, 2005). These activated pathways alter the DNA synthesis along with cell growth, differentiation, and others. Almost all the TKI have side effects. The common side effects of TKI are anaemia, neutropenia, oedema, thrombopenia, hypothyroidism, diarrhoea, and vomiting (Hartmann et al., 2009). At the same time, TKI molecules are now approved for clinical trials in human. TKI application for cancer treatment in dogs and cats was approved earlier, with TKI drugs such as Palladia (Toceranid), Gleevec (imatinid) and Kinavet (mastinib) (London, 2009). Before conducting the safety pharmacology tests, the regulatory guidelines for testing the undesirable pharmacodynamics effects on physiological functions should be focused. This is because, in the early phase pharmacology studies, all risk factors can be found out and eliminated. TKI are found to have adverse cardiovascular effects. So, when testing TKI in dogs and cats, telemetry has to be used for the continuous monitoring of systemic arterial pressure and chronotropic effects. The pharmacodynamic effects of TKI can be determined in the organs using tumor specimens. Surrogate marker can be used as an alternative approach. These tissues act as human models and TKI effect on these tissues reveals the potential effects of TKI molecules. (Kufe et al., 2003). These pharmacological screening methods enable the scientists to find out the adverse effects of TKI, and facilitate them to come up with ways on how the programme should be modified for human safety. The effect of the drug in or gan function, and importantly the relevance of its potential in humans

No topic Assignment Example | Topics and Well Written Essays - 500 words - 17

No topic - Assignment Example Hence, it is advisable that the Christians with the heart of helping the needy should not spoon feed them, but provide them with guidelines on how they can solve their problems and come out of their situations. Bob Lupton, Bart Fikkert, and Melissa Dodson realized that the people being helped had the capacity and capability of doing the things that they were a help. For instance, they observed that persons whose streets were littered and charity works were geared towards cleaning their streets had the capacity including physical fitness to undertake these tasks by themselves. Additionally, they realized that the people who were being helped by charities became lazy to perform tasks that could help them obtain what they were provided with yet they were in positions to do the same. Therefore, these charity works only increased their dependency on handouts from the charity organization or people. These circumstances are different from other circumstances that these authors highly criticized. Obviously, the natural disasters are usually emergencies that people need to be helped out of or help to recover to their normal ways of life. In these cases, Bob Lupton, Steve Corbett, and Brian Fikkert may not criticize persons, organizations, or religions that provide charity to these people. Notably, after a well-coordinated response by the government among other relevant agencies to these emergencies, the affected persons from natural disasters are expected to resume their normal life. Therefore, they are not expected to depend on the charity for the rest of their lives; hence, Bob Lupton, Steve Corbett, and Brian Fikkert may support individuals to provide such groups with charitable services and goods. Relief is an urgent, but temporary aid provided to reduce suffering following a man-made or natural disaster. On the other hand, rehabilitation are is reconstruction steps that are often undertaken immediately after